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New evidence from mice suggests why an antidepressant treatment can alleviate depression in one person but not another. The study, publishing December 28 in the open access journal PLOS Biology, was led by Marianne Müller and an international team at the University Medical Center Mainz and the Max Planck Institute of Psychiatry. The researchers developed…

Understanding of the physical root of depression has been advanced, thanks to new research. Researchers have identified the lateral orbitofrontal cortex as the area of the brain affected by depression. This discovery could open up possible new treatments, say the researchers. The study shows that depression affects the part of the brain which is implicated…

According to a new study, depression is tied to increased functional connectivity between a brain region that is associated with not receiving rewards and experiencing punishing events (the lateral orbitofrontal cortex) and an area of the brain involved in someone’s sense of self (the precuneus). This cutting-edge discovery was published today in the journal Brain….

Suicide only occasionally makes the national news, but it is the 10th leading cause of death in the U.S. Dr. Insel talks about the need for research targeted directly at suicide and recent efforts to raise awareness and marshal research. …read more

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